Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …

Despite a continuing debate about the existence of cancer stem cells (CSCs), recent
discoveries have provided further support for their existence and their roles in drug …

Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to
drive tumour growth, metastasis and therapy resistance. It has recently been proposed that …

Increased glucose metabolism is now recognized as an emerging hallmark of cancer.
Recent studies have shown that glucose metabolism is even more active in cancer stem …

Aerobic glycolysis, ie., the Warburg effect, may contribute to the aggressive phenotype of
hepatocellular carcinoma. However, increasing evidence highlights the limitations of the …

The principles guiding the design and synthesis of bioactive compounds based on natural
product (NP) structure, such as biology-oriented synthesis (BIOS), are limited by their partial …