Thalassemia, a chronic disease with chronic anemia, is caused by mutations in the β-globin
gene, leading to reduced levels or complete deficiency of β-globin chain synthesis. Patients …

The immune response generated by the body after the incidence of ischemic stroke, runs
through the comprehensive process of aftermath. During this process of ischemic stroke, the …

Introduction Thalassemias are treated by regular blood transfusions and iron chelation
therapy. Iron overload-induced oxidative stress helps the pathogenesis of thalassemia …

Background and aims Thalassemia syndromes are the most common hemoglobinopathy
globally related to blood transfusion and iron overload in the body. Splenectomy, excessive …

Beta-thalassemia major patients are treated with repeated blood transfusions, which may
cause iron overload, which in turn may induce immune aberrations, and show an increased …

Objectives In Gaza Strip, Palestine, β-thalassemia is a major public health problem where
more than 300 β-thalassemia major (βTM) patients are currently being managed at …

Results: It seems that persistent antigenic stimulation and oxidative stress from excessive
iron are the two main pathophysiologic factors of TM impacting the immune system …

Increased Risk of Hemorrhagic and Ischemic Strokes in Patien... : Medicine Increased Risk of
Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A …

Background: Transfusion dependent thalassemia (TDT) patients are treated with continued
blood transfusions and show a higher prevalence of depression. TDT with consequent iron …

Severe bacterial infection is a major complication causing morbidity and mortality in β‐
thalassaemia/HbE patients. Innate immunity constitutes the first line of defence against …