Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …

Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

Diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold
hopping, isosteric replacement, high-throughput screening, induction and separation of …

The present study involves design and synthesis of five series of 6-bromo-2-(pyridin-3-yl)-4-
substituted quinazolines 9a-l, 11a-e, 13a-c, 14a-f and 15a-e. Candidates 9a-l and 11a-e …

A transition-metal-free strategy regarding an iodine–sodium percarbonate catalysis to
achieve the ortho-aminomethylation of phenols in aqueous media has been developed. This …

Modification of the parent structure of molecules often alters their physicochemical
properties and biological activities. Herein, a practical, efficient, and highly regioselective C …

We developed a Cr-catalyzed strategy for the regioselective formation of Csp2–Csp3 bonds
through the direct and efficient ortho-aminomethylation of N, N-dimethylanilines with …

Abstract Poly (ADP-ribose) polymerase (PARP) is a significant therapeutic target for the
treatment of numerous human diseases. Olaparib has been approved as a PARP inhibitor …

PARP7 has been proven to play an important role in immunity. Substantial upregulation of
PARP7 is observed in numerous cancerous cell types, consequently resulting in the …

Guaiazulene and related derivatives were famous for diverse biological activities. In an effort
to discover new highly efficient candidate drugs derived from guaiazulene, four series of …