The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …

Causal molecular interactions represent key building blocks used in computational
modeling, where they facilitate the assembly of regulatory networks. Logical regulatory …

The 'precision medicine (systems medicine)'concept promises to achieve a shift to future
healthcare systems with a more proactive and predictive approach to medicine, where the …

Wildlife populations are under intense anthropogenic pressures, with the geographic range
of many species shrinking, dramatic reductions in population numbers and undisturbed …

The current species extinction crisis is being exacerbated by an increased rate of
emergence of epizootic disease. Human‐induced factors including habitat degradation, loss …

Background Retinoid therapy is widely employed in clinical oncology to differentiate
malignant cells into their more benign counterparts. However, certain high-risk cohorts, such …

Chemical reaction networks are powerful tools for modeling cell signaling and its disruptions
in diseases like cancer. Realistic chemical reaction networks involve hundreds of proteins …

Wnt signalling is involved in the formation, metastasis and relapse of a wide array of
cancers. However, there is ongoing debate as to whether activation or inhibition of the …

Colorectal cancer (CRC) is one of the most deadly and commonly diagnosed tumors
worldwide. Several genes are involved in its development and progression. The most …

In this work we present a fast, globally convergent, iterative algorithm for computing the
asymptotically stable states of nonlinear large--scale systems of quadratic autonomous …