The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …

The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

A central goal of precision medicine is to predict disease outcomes and design treatments
based on multidimensional information from afflicted cells and tissues. Cell morphology is …

Cancer invasion through dense extracellular matrices (ECMs) is mediated by matrix
metalloproteinases (MMPs) which degrade the ECM thereby creating paths for migration …

Mechanical interactions between cells and their microenvironment dictate cell phenotype
and behavior, calling for cell mechanics measurements in three-dimensional (3D) …

Metastasis is a fundamentally physical process in which cells are required to deform through
narrow gaps as they invade surrounding tissues and transit to distant sites. In many cancers …

To investigate the transition from non-cancerous to metastatic from a physical sciences
perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed …

Metastasis is the leading cause of cancer-related deaths, but it is unclear how cancer cells
escape their primary sites in epithelia and disseminate to other sites in the body. One …

Cell migration plays a pivotal role in many physiologically important processes such as
embryogenesis, wound-healing, immune defense, and cancer metastasis. Although much …

Intratumoral heterogeneity greatly complicates the study of molecular mechanisms driving
cancer progression and our ability to predict patient outcomes. Here we have developed an …