Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

l-Arginine is involved in many different biological processes and recent reports indicate that
it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the …

Long COVID, a condition characterized by symptom and/or sign persistence following an
acute COVID-19 episode, is associated with reduced physical performance and endothelial …

Background We and others have previously demonstrated that the endothelium is a primary
target of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and L …

Low plasma arginine bioavailability has been implicated in endothelial dysfunction and
immune dysregulation. The role of arginine in COVID-19 is unknown, but could contribute to …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. In sepsis, a complicated immune response is initiated, which varies over time with …

SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …

The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients.
Differences in the type and degree of inflammation appear to determine the severity of the …

Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms,
defined as long COVID (LC), that may last months or years post the onset of acute disease …