Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it
regulates the host response to infections by driving T helper (Th) polarization and acting on …

Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of
articular cartilage, inflammation, and changes in periarticular and subchondral bone of …

Knee osteoarthritis (KOA) is a common degenerative joint disease causing pain, stiffness,
reduced motion, swelling, crepitus, and disability. Several inflammatory markers and …

Osteoarthritis is a heterogeneous disease characterized by variable clinical features,
biochemical/genetic characteristics, and responses to treatments. To optimize palliative …

Osteopontin (OPN) has been proved to be closely related to the pathogenesis of
osteoarthritis (OA), but the role of OPN in the pathogenesis of OA has not been fully clarified …

Osteoarthritis (OA) is a whole-joint disorder, and non-cartilage articular pathologies, eg
subchondral bone disturbance, contribute substantially to the onset and progression of the …

Objective To investigate the relationship between leptin, osteopontin (OPN), sclerostin
(SOST) and severity of knee osteoarthritis (KOA). Methods The study included 148 …

Purpose Recent evidence suggests that angiogenesis and inflammation contribute to the
development and progression of osteoarthritis (OA). The purpose of this study was to …

Articular cartilage is a skeletal tissue of avascular nature and limited self-repair capacity.
Cartilage-degenerative diseases, such as osteoarthritis (OA), are difficult to treat and often …

Osteoarthritis (OA) is a degenerative disease, which is characterized by articular cartilage
destruction, and mainly affects the older people. The extracellular matrix (ECM) provides a …