Toxoplasmosis: Current and emerging parasite druggable targets

RE Hajj, L Tawk, S Itani, M Hamie, J Ezzeddine… - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a prevalent disease affecting a wide range of hosts including
approximately one-third of the human population. It is caused by the sporozoan parasite …

Human cyclosporiasis

A Giangaspero, RB Gasser - The Lancet Infectious Diseases, 2019 - thelancet.com
Cyclospora species are socioeconomically important protistan pathogens. Cyclospora
cayetanensis is usually transmitted via food or water to a human host via the faecal–oral …

Toxoplasma gondii infection: novel emerging therapeutic targets

J Müller, A Hemphill - Expert opinion on therapeutic targets, 2023 - Taylor & Francis
Introduction Toxoplasmosis constitutes a challenge for public health, animal production, and
welfare. So far, only a limited panel of drugs has been marketed for clinical applications. In …

Identification of putative drug targets in Vancomycin-resistant Staphylococcus aureus (VRSA) using computer aided protein data analysis

MA Hasan, MA Khan, T Sharmin, MHH Mazumder… - Gene, 2016 - Elsevier
Vancomycin-resistant Staphylococcus aureus (VRSA) is a Gram-positive, facultative aerobic
bacterium which is evolved from the extensive exposure of Vancomycin to Methicillin …

Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in apicoplast and mitochondrial genomes

K Tang, Y Guo, L Zhang, LA Rowe, DM Roellig… - Parasites & …, 2015 - Springer
Background Cyclospora cayetanensis is an important cause for diarrhea in children in
developing countries and foodborne outbreaks of cyclosporiasis in industrialized nations. To …

Therapy for ocular toxoplasmosis–the future

JG Garweg, MR Stanford - Ocular immunology and inflammation, 2013 - Taylor & Francis
Background: Treatment of ocular toxoplasmosis is aimed at stabilizing visual function and
reducing recurrence rates. Methods: Small controlled studies indicate that available …

Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine …

V Kushwaha, V Kumar, SK Verma, R Sharma… - Vaccine, 2014 - Elsevier
We have recently identified disorganized muscle protein-1 (DIM-1) in one of the
proinflammatory fractions of the human filaria Brugia malayi adult worm. The present study …

Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49

Z Ma, AMM Alhameed, AC Kaminga, B Lu, X Li… - Microbial …, 2020 - Elsevier
Toxoplasma gondii is an obligate intracellular parasite that is globally distributed and can
infect almost all warm-blooded animals, including humans. While vaccines are not available …

Predictions of enzymatic parameters: a mini-review with focus on enzymes for biofuel

S Yan, G Wu - Applied biochemistry and biotechnology, 2013 - Springer
Enzymatic reactions are very basic processes in biological systems, and parameters related
to enzymatic reactions always provide good indicators for understanding of mechanisms …

Therapeutic Targets on Toxoplasma gondii parasite in combatting Toxoplasmosis

SA Abdullahi, NZ Unyah, N Nordin… - … & Review in …, 2019 - science.sdpublishers.org
The status of toxoplasmosis management is challenged by drug intolerance, compromised
efficacy and potential development of drug resistance. However, currently, there are very …