Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human
physiology. Due to the widespread expression of adenosine receptors, it has far-reaching …

Pressure wire–based fractional flow reserve is considered the standard of reference for
evaluation of the ischemic potential of coronary stenoses and the expected benefit from …

Background In patients with coronary artery disease who are being evaluated for
percutaneous coronary intervention (PCI), procedures can be guided by fractional flow …

Background The instantaneous wave-free ratio (iFR) is an index used to assess the severity
of coronary-artery stenosis. The index has been tested against fractional flow reserve (FFR) …

Aims The microvascular resistance reserve (MRR) was introduced as a means to
characterize the vasodilator reserve capacity of the coronary microcirculation while …

Angina and myocardial ischemia without obstructive coronary artery disease are common
clinical findings, often neglected for the assumption of a good prognosis. Most often, such …

Coronary artery disease (CAD) is a leading global cause of morbidity and mortality, and
improvements in the diagnosis and treatment of CAD can reduce the health and economic …

Objectives The aim of this study was to demonstrate the clinical implications of combined
assessment of fractional flow reserve (FFR) and coronary flow reserve (CFR). Background …

Objectives: This study sought to evaluate the prognostic value of post–percutaneous
coronary intervention (PCI) distal coronary pressure to aortic pressure ratio (Pd/Pa) in …

In this document, the background, concept, and current evidence are briefly summarized.
The focus is on the clinical application of physiological lesion assessment from a practical …