Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-
year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with …

Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …

Simple Summary Cell-to-cell communication between the immune system and tumors is of
the utmost importance; it influences the development of tumors, their growth, and how they …

T cell-based immunotherapies have exhibited promising outcomes in tumor control;
however, their efficacy is limited in immune-excluded tumors. Cancer-associated fibroblasts …

Evolution of tumor hallmarks is a result of accommodation of tumor cells with their nearby
milieu called tumor microenvironment (TME). Accommodation or adaptive responses is …

Previously, impaired responses to immunotherapy in cancer had been attributed mainly to
inherent tumor characteristics (tumor cell intrinsic factors) such as low immunogenicity,(low) …

Immunotherapies have revolutionized cancer treatment, but despite the many lives that have
been extended by these therapies many patients do not respond for reasons that are not …

Cancer-associated fibroblasts (CAFs) play a role in ovarian cancer (OV) evolution,
immunosuppression and promotion of drug resistance. Exploring the value of CAFs-related …

Simple Summary Breast cancer is one of the most common forms of cancer in women.
Treatment options include immunotherapy where elements of the immune system are used …

The interaction between the tumour and the surrounding microenvironment determines the
malignant biological behaviour of the tumour. Cancer-associated fibroblasts (CAFs) …