The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

Successful goal-directed behavior requires not only correct action selection, planning, and
execution but also the ability to flexibly adapt behavior when performance problems occur or …

Anterior cingulate cortex (ACC) is a part of the brain's limbic system. Classically, this region
has been related to affect, on the basis of lesion studies in humans and in animals. In the …

Intense research interest over the past decade has yielded diverse and often discrepant
theories about the function of anterior cingulate cortex (ACC). In particular, a dichotomy has …

Emerging evidence has shown that social pain—the painful feelings that follow from social
rejection, exclusion, or loss—relies on some of the same neural regions that process …

There is now a wealth of evidence that anterior insular and anterior cingulate cortices have a
close functional relationship, such that they may be considered together as input and output …

Influential theoretical models propose a central role for afferent information from the body in
the expression of emotional feeling states. Feedback representations of changing states of …

Human anterior cingulate function has been explained primarily within a cognitive
framework. We used functional MRI experiments with simultaneous electrocardiography to …

Objective Spinal cord stimulation via epidurally implanted electrodes is a common treatment
for medically intractable neuropathic pain of different origins. Because tonic electrical …

As a social species, humans have a fundamental need to belong that encourages behaviors
consistent with being a good group member. Being a good group member requires the …