Astrocytes are now known to be involved in the most integrated functions of the central
nervous system. These functions are not only necessary for the normally working brain but …

Oxidative and nitrosative stress (ONS) contributes to the pathogenesis of most brain
maladies, and the magnitude of ONS is related to the ability of cellular antioxidants to …

Oxidative stress is believed to be the cause of cell death in multiple disorders of the brain,
including perinatal hypoxia/ischemia. Glutamate, cystine deprivation, homocysteic acid, and …

Apoptosis‐inducing factor (AIF) triggers apoptosis in a caspase‐independent manner. Here
we report for the first time involvement of AIF in neuronal death induced by cerebral …

The developing and the adult brain respond in similar ways to ischemia, but also display
clear differences. For example, the relative contributions of necrosis and apoptosis to …

OBJECTIVES:: To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for
the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and …

Hypoxic‐ischaemic encephalopathy, resulting from asphyxia during birth, affects 2–3 in
every 1000 term infants and depending on severity, brings about life‐changing neurological …

Oxidative injury to premyelinating oligodendrocytes (preOLs) in developing white matter has
been implicated in the pathogenesis of periventricular leukomalacia, the lesion underlying …

Perturbation of mitochondrial function and subsequent induction of cell death pathways are
key hallmarks in neonatal hypoxic-ischemic (HI) injury, both in animal models and in term …

Neonatal hypoxia–ischemia (HI) and the delayed injury cascade that follows involve
excitotoxicity, oxidative stress and mitochondrial failure. The susceptibility to excitotoxicity of …