Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …

Circadian rhythms regulate various processes in the human body, including drug
metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the …

The discovery that half of the mammalian protein-coding genome is regulated by the
circadian clock has clear implications for medicine. Recent studies demonstrated that the …

Colorectal cancer (CRC) is a lethal malignancy with limited treatment strategies.
Accumulating evidence indicates that CRC tumorigenesis, progression and metastasis are …

Recent studies have established that the circadian clock influences onset, progression and
therapeutic outcomes in a number of diseases including cancer and heart diseases …

Although much has been learned about circadian clocks and rhythms over the past few
decades, translation of this foundational science underlying the temporal regulation of …

Purpose Many brain tumor patients suffer from radiation-induced toxicities. Chronotherapy is
a treatment modality that utilizes circadian rhythms to optimize the effect on tumor while …

Initial clinical reports comparing the delivery of radiotherapy (RT) at distinct times of the day
suggest that this strategy might affect toxicity and oncologic outcomes of radiation for …

A minority of radiotherapy patients experience adverse reactions as a result of the inevitable
irradiation of the surrounding healthy tissue. These reactions range in severity and affect the …

Five decades ago, Franz Halberg conceived the idea of​​ a circadian-based therapy for
cancer, given the differential tolerance to treatment derived from the intrinsic host rhythms …