Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

Proteomic profiling of brain cell types using isolation-based strategies pose limitations in
resolving cellular phenotypes representative of their native state. We describe a mouse line …

The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited,
neurodegenerative disease caused by an expansion of polyglutamine tracts in the cytosolic …

Within the closing decade of the twentieth century, 14 neurological disorders were shown to
result from the expansion of unstable trinucleotide repeats, establishing this once unique …

Huntington's disease (HD) is an autosomal dominant, fatal disorder. Patients display
increasing motor, psychiatric and cognitive impairment and at autopsy, late-stage patient …

Mutations in the CACNA1A gene that encodes the pore-forming α 1 subunit of human
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channels cause several autosomal-dominant …

Throughout the genome, unstable tandem nucleotide repeats can expand to cause a variety
of neurologic disorders. Expansion of a CAG triplet repeat within a coding exon gives rise to …

Ataxia is a neurological disorder characterized by loss of control of body movements.
Spinocerebellar ataxia (SCA), previously known as autosomal dominant cerebellar ataxia, is …