Nuclear receptors regulate many biologically important processes in development and
homeostasis by their bimodal function as repressors and activators of gene transcription. A …

The three mammalian Runt homology domain transcription factors (Runx1, Runx2, Runx3)
support biological control by functioning as master regulatory genes for the differentiation of …

Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …

Recent transcriptome analyses have revealed that a large body of noncoding regions of
mammalian genomes are actually transcribed into RNAs. Our understanding of the …

Abstract The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9
(MMP9) are key regulators of growth plate maturation and bone formation. The genes for …

Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …

Genomes are housed within cell nuclei as individual chromosome territories. Nuclei contain
several architectural structures that interact and influence the genome. In this review, we …

RuvBL1 is an evolutionarily highly conserved eukaryotic protein belonging to the AAA+-
family of ATPases (ATPase associated with diverse cellular activities). It plays important …

Runx transcription factors comprise a family of proteins that are essential for organogenesis.
A unique nuclear matrix-targeting signal in the C terminus directs these factors to their …

In mammals, oocyte acquires a series of competencies sequentially during folliculogenesis
that play critical roles at fertilization and early stages of embryonic development. In mouse …