▪ Abstract DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects
mismatches generated during DNA replication and escape proofreading. MMR proteins also …

Mutations are rare events, occurring spontaneously at a frequency of 1 per 109-1010 base
pairs per cell division. 1, 2 Nucleotide misincorporation during DNA synthesis yields …

DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important
cellular functions. In its role in post-replication repair, MMR safeguards the genome …

▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …

Bacteria are continuously exposed to numerous endogenous and exogenous DNA-
damaging agents. To maintain genome integrity and ensure cell survival, bacteria have …

▪ Abstract Chromosomal DNA replicases are multicomponent machines that have evolved
clever strategies to perform their function. Although the structure of DNA is elegant in its …

▪ Abstract DNA mismatch repair (MMR) guards the integrity of the genome in virtually all
cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …

The joining of interruptions in the phosphodiester backbone of duplex DNA is critical for
maintaining genomic integrity. DNA strand-breaks are produced as a consequence of …

The interaction between DNA polymerases and sliding clamp proteins confers processivity
in DNA synthesis. This interaction is critical for most DNA replication machines from viruses …

High accuracy (fidelity) of DNA replication is important for cells to preserve the genetic
identity and to prevent the accumulation of deleterious mutations. The error rate during DNA …