Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

Although it is a relatively rare disease, primarily found in the Caucasian population, uveal
melanoma is the most common primary intraocular tumor in adults with a mean age …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular
malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop …

Uveal melanoma (UM) is the most common intraocular malignancy and arises from
melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is …

The overall survival (OS) of patients with metastatic uveal melanoma is short, the evidence
for effectiveness of treatments is limited, and no consensus on the choice of treatment exists …

Background Despite the completion of numerous phase II studies, a standard of care
treatment has yet to be defined for metastatic uveal melanoma (mUM). To determine …

Importance Uveal melanoma is characterized by mutations inGNAQandGNA11, resulting in
mitogen-activated protein kinase pathway activation. Objective To assess the efficacy of …

Uveal melanoma is the most common primary malignant tumor of the eye in adults,
predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet …

Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …