Translocation and unwinding mechanisms of RNA and DNA helicases
AM Pyle - Annu. Rev. Biophys., 2008 - annualreviews.org
Helicases and remodeling enzymes are ATP-dependent motor proteins that play a critical
role in every aspect of RNA and DNA metabolism. Most RNA-remodeling enzymes are …
role in every aspect of RNA and DNA metabolism. Most RNA-remodeling enzymes are …
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
M Gu, CM Rice - Proceedings of the National Academy of …, 2010 - National Acad Sciences
A virally encoded superfamily-2 (SF2) helicase (NS3h) is essential for the replication of
hepatitis C virus, a leading cause of liver disease worldwide. Efforts to elucidate the function …
hepatitis C virus, a leading cause of liver disease worldwide. Efforts to elucidate the function …
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target
Hepatitis C virus non-structural protein 3 contains a serine protease and an RNA helicase.
Protease cleaves the genome-encoded polyprotein and inactivates cellular proteins …
Protease cleaves the genome-encoded polyprotein and inactivates cellular proteins …
Single-molecule analysis and engineering of DNA motors
Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …
work and, in doing so, perform critical cellular functions such as DNA replication and …
Overview of HCV life cycle with a special focus on current and possible future antiviral targets
N Alazard-Dany, S Denolly, B Boson, FL Cosset - Viruses, 2019 - mdpi.com
Hepatitis C infection is the leading cause of liver diseases worldwide and a major health
concern that affects an estimated 3% of the global population. Novel therapies available …
concern that affects an estimated 3% of the global population. Novel therapies available …
Cellular and molecular biology of HCV infection and hepatitis
H Tang, H Grisé - Clinical science, 2009 - portlandpress.com
HCV (hepatitis C virus) infects nearly 3% of the population worldwide and has emerged as a
major causative agent of liver disease, resulting in acute and chronic infections that can lead …
major causative agent of liver disease, resulting in acute and chronic infections that can lead …
Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes
The hepatitis C virus NS2 protein has been recently implicated in virus particle assembly. To
further understand the role of NS2 in this process, we conducted a reverse genetic analysis …
further understand the role of NS2 in this process, we conducted a reverse genetic analysis …
Hepatitis C virus replication
K Tabata, CJ Neufeldt… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Replication and amplification of the viral genome is a key process for all viruses. For
hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome …
hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome …
Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity
Chikungunya virus (CHIKV) non-structural protein 2 (nsP2) is a multifunctional protein that is
considered a master regulator of the viral life cycle and a main viral factor responsible for …
considered a master regulator of the viral life cycle and a main viral factor responsible for …