The alarming spread of bacterial strains exhibiting resistance to current antibiotic therapies
necessitates that we elucidate the specific genetic and biochemical responses underlying …

In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …

One of the most terrible consequences of Darwinian evolution is arguably the emergence
and spread of antibiotic resistance, which is becoming a serious menace to modern …

The SOS response of bacteria is a global regulatory network targeted at addressing DNA
damage. Governed by the products of the lexA and recA genes, it co-ordinates a …

The main causes of antibiotic resistance are the selection of naturally occurring resistant
variants and horizontal gene transfer processes. In recent years, the implications of antibiotic …

High accuracy (fidelity) of DNA replication is important for cells to preserve the genetic
identity and to prevent the accumulation of deleterious mutations. The error rate during DNA …

Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics.
Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves …

Diversity in adaptive responses is common within species and populations, especially when
the heterogeneity of the frequently large populations found in environments is considered …

Replication forks are impeded by DNA damage and protein–nucleic acid complexes such as
transcribing RNA polymerase. For example, head-on collision of the replisome with RNA …

All organisms possess a diverse set of genetic programs that are used to alter cellular
physiology in response to environmental cues. The gram-negative bacterium Escherichia …