Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids
are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl …

The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

Covering: up to 2011 This review summarises the accumulated knowledge about the
stereochemical courses of biosynthetic reactions to isoprenoids. Important pathways of the …

IPP (isopentenyl diphosphate) and DMAPP (dimethylallyl diphosphate) serve as the
universal precursors for the biosynthesis of isoprenoids. Besides the well-known …

The IspG protein is known to catalyze the transformation of 2-C-methyl-d-erythritol 2, 4-
cyclodiphosphate into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the …

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …

Taxadiene is the first dedicated intermediate in the biosynthetic pathway of the anticancer
compound Taxol. Recent studies have taken advantage of heterologous hosts to produce …

1-Deoxy-d-xylulose 5-phosphate (DXP) reductoisomerase (DXR, also known as methyl-d-
erythritol 4-phosphate (MEP) synthase) is a NADPH-dependent enzyme, which catalyzes …

In this review article recent isotopic labelling experiments are presented that served in the
elucidation of the complex mechanisms of terpene biosynthesis. The article is structured by …

To expand the structure–activity relationships of fosmidomycin and FR900098, two potent
antimalarials interfering with the MEP-pathway, we decided to replace a methylene group in …