Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical …

Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-
related death and is the most lethal of common malignancies with a five-year survival rate …

Telomeres are responsible for protecting chromosome ends in order to prevent the loss of
coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and …

Telomerase activity and (human) Telomerase Reverse Transcriptase (hTERT) expression
are considered hallmarks in oncogenesis of neoplasms and are upregulated by alterations …

Telomerase promoter (TERTp) mutations are frequently observed in various types of
tumours and commonly characterised by two specific hotspots located at positions− 124 …

Background Mutations in the telomerase reverse transcriptase (TERT) promoter region have
been proposed as novel mechanisms for the transcriptional activation of telomerase. Two …

Cancer cells activate a telomere maintenance mechanism like telomerase in order to
proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase …

Telomere maintenance is a critical requirement for enabling replicative immortality and
tumour development. Here, telomerase expression and activity, telomere length (TL) and …

Genetic and epigenetic alterations of the telomere maintenance machinery like telomere
length and telomerase reverse transcriptase (encoded by TERT gene) are reported in …