Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …

DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …

BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours
hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. To understand the …

To ward off against the catastrophic consequences of persistent DNA double-strand breaks
(DSBs), eukaryotic cells have developed a set of complex signaling networks that detect …

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …

B cells generate functionally different classes of antibodies through class-switch
recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to …

Early work from about two decades ago implicated DNA double-strand break (DSB)
formation and repair in neuronal development. Findings emerging from recent studies of …

Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B
cells that diversifies the effector component of antibody responses. CSR is initiated by the …

SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to
counteract DNA double-strand break (DSB) end resection and promote DNA repair via non …

Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered
genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic …