Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …

Our aim was identify brain areas involved in the premonitory phase of migraine using
functional neuroimaging. To this end, we performed positron emission tomography scans …

Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in
external jugular venous blood during migraine attacks. However, it is unknown whether this …

Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

The most important primary headaches (ie independent disorders that are not caused by
another disease) are migraine, tension-type headache and cluster headache. All primary …

Cluster headache, the most severe primary headache, is characterised by unilateral pain,
ipsilateral autonomic features, and, in many cases, restlessness. Recent epidemiological …

Migraine is considered a neurovascular disease involving dilatation of cerebral arteries.
Nitric oxide (NO) donors induce dilatation of cerebral and extracranial arteries and migraine …

Primary headaches such as migraine and cluster headache are neurovascular disorders.
Migraine is a painful, incapacitating disease that affects a large portion of the adult …

Despite evidence emerging from the experimental model of nitroglycerin-induced headache,
the endogenous increase in nitric oxide (NO) production during migraine attacks is only …