Extensively characterized, modified, and employed for a variety of purposes, adenovirus
(Ad) vectors are generally regarded as having great potential by many applied virologists …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

Adenoviruses have been studied intensively for over 50 years as models of virus–cell
interactions and latterly as gene vectors. With the advent of more sophisticated structural …

Recombinant adenoviral vectors have been widely used for gene therapy applications and
as vaccine vehicles for treating infectious diseases such as human immunodeficiency virus …

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

Adenovirus is a highly evolutionary successful pathogen, as it is widely prevalent across the
animal kingdom, infecting hosts ranging from lizards and frogs to dolphins, birds, and …

The chemical modification of adenovirus (Ad) gene transfer vectors with synthetic polymers
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …

Over the last decade, pioneering liver-directed gene therapy trials for haemophilia B have
achieved sustained clinical improvement after a single systemic injection of adeno …

Adenovirus (Ad) vectors are promising candidates for both gene transfer and vaccine
applications. In this study, we investigated the role of TLR2 in innate and adaptive immune …

Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the
treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad …