Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to
explore non-conventional therapeutic measures to alleviate the burden of CVD on global …

Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …

Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

Covalent attachment (conjugation) of one or more ubiquitin molecules to protein substrates
governs numerous eukaryotic cellular processes, including apoptosis, cell division and …