The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial
activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator …

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

Canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity,
but the molecular mechanism by which this is achieved remains unclear. Here, we report …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in
embryonic and post-embryonic development across the animal kingdom. As a result …

Multiple signaling pathways, including Wnt signaling, participate in animal development,
stem cell biology, and human cancer. Although many components of the Wnt pathway have …

Highlights•Protein liquid-liquid phase separation has implications for cellular
signaling.•Multivalent interactions give liquid, non-membrane-contained phase-separated …

Cancer development depends on the aberrant activation of signal transduction pathways
that control cell growth and survival and play important roles in normal embryonic …