This review summarises the evidence that chronic low grade inflammation triggers changes
that contribute to the mental and physical ill health of patients with major depression …

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central
nervous system (CNS). It is essential for the development of the CNS and for neuronal …

Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The
dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is …

Cortical growth and remodeling continues from birth through youth and adolescence to
stable adult levels changing slowly into senescence. There are critical periods of cortical …

Depression is one of the most prevalent and life-threatening forms of mental illnesses and
the neural circuitry underlying depression remains incompletely understood. Most attention …

BACKGROUND: Clinical trial data provide an approach to the investigation of the effects of
psychopharmacological agents, and psychiatric disorders themselves, on seizure threshold …

Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family of structurally
related proteins that promote neuronal differentiation and survival during development [1, 2] …

Depression is one of the most prevalent and life-threatening forms of mental illnesses,
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …

Ketamine produces rapid and robust antidepressant effects in depressed patients within
hours of administration, often when traditional antidepressant compounds have failed to …

The selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
pharmacological treatment for depression. Since their introduction many have considered …