The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis
elegans, and its biological functions show a high level of evolutionary conservation from the …

The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the
nematode Caenorhabditis elegans and control the timing of stem-cell division and …

Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …

MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene
expression at the translational level. Current evidence suggests that a significant portion of …

Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic
development and physiology. Amidst an extensive regulatory web that is predicted to involve …

MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene
regulation in a plethora of tissues, including the nervous system. Recent evidence points to …

The p53 transcription factor is a key tumor suppressor and a central regulator of the stress
response. To ensure a robust and precise response to cellular signals, p53 gene expression …

MicroRNAs (miRNAs) are small noncoding RNAs,∼ 22 nucleotides in length, that repress
target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was …

Rationale: Heart failure is a deadly and devastating disease that places immense costs on
an aging society. To develop therapies aimed at rescuing the failing heart, it is important to …

The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …