Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons.
They degenerate in multiple neurological disorders. However, their role in the pathogenesis …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …