Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA
function including amino acid substitution to give proteins not encoded in the genome. What …

The lesion bypass pathway, translesion synthesis (TLS), exists in essentially all organisms
and is considered a pathway for postreplicative gap repair and, at the same time, for lesion …

DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the
genome in all living organisms. dPols catalyze the formation of a phosphodiester bond …

Recent studies posit that reactive oxygen species (ROS) contribute to the cell lethality of
bactericidal antibiotics. However, this conjecture has been challenged and remains …

In order to cope with the risk of stress-induced mutagenesis, cells in all kingdoms of life
employ Y-family DNA polymerases to resolve resulting DNA lesions and thus maintaining …

In A-family DNA polymerases (dPols), a functional 3′-5′ exonuclease activity is known to
proofread newly synthesized DNA. The identification of a mismatch in substrate DNA leads …

The presence of ribonucleotides in DNA can lead to genomic instability and cellular lethality.
To prevent adventitious rNTP incorporation, the majority of the DNA polymerases (dPols) …

The evolutionarily conserved Escherichia coli translesion DNA polymerase IV (DinB) is one
of three enzymes that can bypass potentially deadly DNA lesions on the template strand …

Apicomplexans such as the malaria parasite Plasmodium falciparum possess a unique
organelle known as the apicoplast that has its own circular genome. The apicoplast genome …

N 2-Furfuryl-deoxyguanosine (fdG) is carcinogenic DNA adduct that originates from furfuryl
alcohol. It is also a stable structural mimic of the damage induced by the nitrofurazone family …