A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

Background Recent research suggests that epigenetic modifications may mediate the
behavioral effects of cannabis, influencing exocannabinnoids' long term effects in cognitive …

Human phenotypes (traits) are determined by the selective use of a person's unique
genotype (DNA sequence), following exposure to environmental stimuli, such as exercise …

The dopaminergic system is a crucial element of the addiction processes. The dopamine
transporter modulates the dynamics and levels of released dopamine in the synaptic cleft …

Objective The impact of adolescent cannabis use is a pressing public health question owing
to the high rates of use and links to negative outcomes. This study considered the …

Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood.
DNA methylation can serve as a mediator to link environmental exposures to health …

The association between extent of chronic cannabis use (CCU-extent) and cognitive
impairment among adolescents has been the subject of controversial debate. Linking DNA …

DNA methylation (leading to gene silencing) is one of the best-studied epigenetic
mechanisms. It is also essential in regulating the dynamics of dopamine release in the …

Compared to other addictive substances, patients with cannabis addiction are significantly
outnumbered by those who report dependence on other, more addictive substances …