Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

Schizophrenia is a disabling mental illness that is now recognized as a neurodevelopmental
disorder. It is likely that genetic risk factors interact with environmental perturbations to affect …

Schizophrenia is a widespread psychiatric disorder that affects 0.5–1.0% of the world's
population and induces significant, long-term disability that exacts high personal and …

In the decade since Disrupted in Schizophrenia 1 (DISC1) was first identified it has become
one of the most convincing risk genes for major mental illness. As a multi-functional scaffold …

Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing
common symptoms with Parkinson's disease (PD). Studies have shown that Mn can …

Although our knowledge of the pathophysiology of schizophrenia has increased, treatments
for this devastating illness remain inadequate. Here, we critically assess rodent models and …

The mood disorders major depressive disorder and bipolar disorder are prevalent, are
inadequately treated, and little is known about their etiologies. A better understanding of the …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Schizophrenia is thought to result from interactions between susceptible genotypes and
environmental risk factors. DISC1 is an important gene for schizophrenia and mood …