Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host

B Singh, C Fleury, F Jalalvand… - FEMS microbiology …, 2012 - academic.oup.com
Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

[HTML][HTML] Syphilis: using modern approaches to understand an old disease

EL Ho, SA Lukehart - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and
both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the …

[HTML][HTML] The global roadmap for advancing development of vaccines against sexually transmitted infections: update and next steps

SL Gottlieb, CD Deal, B Giersing, H Rees, G Bolan… - Vaccine, 2016 - Elsevier
Abstract In 2014, the World Health Organization, the US National Institutes of Health, and
global technical partners published a comprehensive roadmap for development of new …

[HTML][HTML] Protein palmitoylation and its role in bacterial and viral infections

J Sobocińska, P Roszczenko-Jasińska… - Frontiers in …, 2018 - frontiersin.org
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which
palmitoyl chain is attached to a cysteine residue via a thioester linkage. S-palmitoylation …

[HTML][HTML] Application of nanotechnology in wood-based products industry: A review

L Jasmani, R Rusli, T Khadiran, R Jalil… - Nanoscale research …, 2020 - Springer
Wood-based industry is one of the main drivers of economic growth in Malaysia. Forest
being the source of various lignocellulosic materials has many untapped potentials that …

[HTML][HTML] A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

KV Lithgow, R Hof, C Wetherell, D Phillips… - Nature …, 2017 - nature.com
Syphilis is a prominent disease in low-and middle-income countries, and a re-emerging
public health threat in high-income countries. Syphilis elimination will require development …

Current status of syphilis vaccine development: need, challenges, prospects

CE Cameron, SA Lukehart - Vaccine, 2014 - Elsevier
Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum
subsp. pallidum. Despite inexpensive and effective antibiotic therapy, syphilis remains a …

[HTML][HTML] Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of …

SA Lukehart, B Molini, A Gomez, C Godornes, R Hof… - Vaccine, 2022 - Elsevier
Syphilis continues to be a significant public health concern worldwide. The disease is
endemic in many low-and middle-income countries, and rates have risen sharply in high …

Bacterial adhesins, the pathogenic weapons to trick host defense arsenal

S Patel, N Mathivanan, A Goyal - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Adhesins are bacterial proteins with host cell adhesive properties. These proteins occur in
diverse architectures, ranging from capsules, vesicles, pili, fimbri, to enzymes. These …

Vaccine development for syphilis

KV Lithgow, CE Cameron - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum,
continues to be a globally prevalent disease despite remaining susceptible to penicillin …