Atorvastatin (ATV), a lipid-lowering agent, has low oral bioavailability due to its poor water
solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 …

The bioactive withanolides of Withania somnifera (WS) are reported to treat acute stress-
induced anxiety and chronic stress-induced depression. However, its biopharmaceutical …

Abstract Genistein (GEN), an isoflavonoid, offers multifunctional biological activities.
However, its poor oral bioavailability, aqueous solubility, extensive metabolism, and short …

This research has aimed to improve the stability and taste-masking properties by developing
nanostructured dosage forms containing Saquinavir. Liquid formulations were developed …

Agomelatine (AGM) is a unique melatonergic antidepressant drug. However, it possesses
low aqueous solubility, first-pass metabolism, and reduced bioavailability. The aim of the …

Cobalamin (vitamin B12), an essential vitamin with low oral bioavailability, plays a vital role
in cellular functions. This research aimed to enhance the absorption of vitamin B12 using …

The poor aqueous solubility and dissolution rate of andrographolide in aqueous
gastrointestinal fluids often cause low oral bioavailability. In this work, Andrographis …

Objective: The study aims to prepare and evaluate febuxostat nanosuspension to improve
oral bioavailability. Methods: Febuxostat nanosuspension was prepared by the solvent …

Purpose The study was aimed at exploring the feasibility of LIPOID SPC-3 as a coprecipitate
carrier to enhance the aqueous solubility and permeability of ranolazine, a BCS class II …

Objective: To improve ATN's solubility, permeability, and dissolution rate of pentaerythritol-
eudragitŪRS100 co-processed excipients (CE) and their potential as a solid dispersion …