Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour
constitutes the basis for many biological processes such as cellular motility, cytoplasmic …

High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer
death in women and the first among gynecological malignancies. Despite an initial response …

Chromosomal instability (CIN) is a hallmark of cancer and comprises structural CIN (S-CIN)
and numerical or whole chromosomal CIN (W-CIN). Recent work indicated that replication …

Chromosomal instability (CIN) comprises continual gain and loss of chromosomes or parts
of chromosomes and occurs in the majority of cancers, often conferring poor prognosis …

Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the
evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus …

BRCA1 (breast cancer type 1 susceptibility protein) is a multifunctional tumor suppressor
involved in DNA damage response, DNA repair, chromatin regulation, and mitotic …

Chromosomal instability (CIN) causes structural and numerical chromosome aberrations
and represents a hallmark of cancer. Replication stress (RS) has emerged as a driver for …

Long noncoding RNAs constitute a major fraction of the eukaryotic transcriptome, and
together with proteins, they intricately fine-tune various growth regulatory signals to control …

A vital constituent of the centrosome involved in regulating the activity of the organelle
during the cell cycle is centrosomal protein (CEP)-72, whose function in the case of human …

Colorectal cancer (CRC) is a very common and lethal disease worldwide. The etiology of the
disease includes genetic and environmental factors. Among environmental factors, the …