Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells
and matrix debris, while activating reparative pathways necessary for scar formation. A …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Fibrotic rigidification following a myocardial infarct is known to impair cardiac output, and it is
also known that cardiomyocytes on rigid culture substrates show a progressive loss of …

Abstract Transforming Growth Factor (TGF)-β is markedly induced and rapidly activated in
the infarcted myocardium. However, understanding of the exact role of TGF-β signaling in …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

A long non-coding RNA (lncRNA), named myocardial infarction associated transcript (MIAT),
has been documented to confer risk of myocardial infarction (MI). The aim of this study is to …

Background The mechanical properties of the extracellular matrix have an important role in
cell growth and differentiation. However, it is unclear as to what extent cancer cells respond …