CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands

J Korbecki, S Grochans, I Gutowska, K Barczak… - International journal of …, 2020 - mdpi.com
CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …

Kaposi sarcoma

E Cesarman, B Damania, SE Krown, J Martin… - Nature reviews Disease …, 2019 - nature.com
Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

L Qin, I Kufareva, LG Holden, C Wang, Y Zheng… - Science, 2015 - science.org
Chemokines and their receptors control cell migration during development, immune system
responses, and in numerous diseases, including inflammation and cancer. The structural …

Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy

DP Dittmer, B Damania - The Journal of clinical …, 2016 - Am Soc Clin Investig
Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8, is
the etiologic agent underlying Kaposi sarcoma, primary effusion lymphoma, and multicentric …

KSHV: immune modulation and immunotherapy

G Broussard, B Damania - Frontiers in immunology, 2020 - frontiersin.org
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with KS, primary
effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own …

Herpesvirus evasion of natural killer cells

S De Pelsmaeker, N Romero, M Vitale… - Journal of …, 2018 - Am Soc Microbiol
Natural killer (NK) cells play an important role in the host response against viral infections
and cancer development. They are able to kill virus-infected and tumor cells, and they …

Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?

MH Razizadeh, A Zafarani… - Cell Communication and …, 2023 - Springer
Innate immunity is the first line of the host immune system to fight against infections. Natural
killer cells are the innate immunity lymphocytes responsible for fighting against virus …

Co-infection of the Epstein–Barr virus and the Kaposi sarcoma-associated herpesvirus

M Böni, L Rieble, C Münz - Viruses, 2022 - mdpi.com
The two human tumor viruses, Epstein–Barr virus (EBV) and Kaposi sarcoma-associated
herpesvirus (KSHV), have been mostly studied in isolation. Recent studies suggest that co …

Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?

B Damania, DP Dittmer - Journal of medical virology, 2023 - Wiley Online Library
This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that
manifests under diverse and divergent circumstances. We begin with a historical …

TGF-β1 Downregulates the Expression of CX3CR1 by Inducing miR-27a-5p in Primary Human NK Cells

S Regis, F Caliendo, A Dondero, B Casu… - Frontiers in …, 2017 - frontiersin.org
Activity of human natural killer (NK) cells against cancer cells is deeply suppressed by TGF-
β1, an immunomodulatory cytokine that is released and activated in the tumor …