Vitexin, a C-glycosylated flavone present in several medicinal herbs, has showed various
pharmacological activities including antinociception. The present study investigated the …

Background Acetaminophen (APAP) induced hepatotoxicity is a clinically important problem.
Up to now, interventive therapy with n-acetylcysteine (NAC) has been considered as a gold …

Paracetamol is the most widely used over-the-counter medication in the world. The
mechanism of action of its analgesic effect was often considered as based on the …

Objectives Pain is considered as a cause of sickness and the most prevalent symptom which
makes people visit a physician. Nowadays, combination therapy is becoming useful to …

Background Hereditary sensory and autonomic neuropathy (HSAN) type II with WNK1/HSN2
gene mutation is a rare disease characterized by early-onset demyelination sensory loss …

Background: N-acetylcysteine (NAC), an acetylated variant of L-cysteine, is commonly used
as an antidote for acetaminophen overdose and antimucolytic agent in chronic obstructive …

Objective (s): The mechanism of hypothermia action of acetaminophen (APAP) remains
unclear even 125 years after its synthesis. Acetaminophen produces hypothermia. The …

Background: Acetaminophen is an analgesic drug that is used safely in therapeutic doses.
At high doses, it causes hepatotoxicity, resulting in hepatic necrosis. Some medications and …

Background: Lornoxicam and iv paracetamol are commonly preferred to be used for
postoperative analgesia. Although Aspirin is a well known non-steroid anti-inflammatory …

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