Fidelity at the molecular level: lessons from protein synthesis
The faithful and rapid translation of genetic information into peptide sequences is an
indispensable property of the ribosome. The mechanistic understanding of strategies used …
indispensable property of the ribosome. The mechanistic understanding of strategies used …
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion
In vivo incorporation of unnatural amino acids by amber codon suppression is limited by
release factor-1–mediated peptide chain termination. Orthogonal ribosome-mRNA pairs …
release factor-1–mediated peptide chain termination. Orthogonal ribosome-mRNA pairs …
Structural basis for translation termination on the 70S ribosome
M Laurberg, H Asahara, A Korostelev, J Zhu… - Nature, 2008 - nature.com
At termination of protein synthesis, type I release factors promote hydrolysis of the peptidyl-
transfer RNA linkage in response to recognition of a stop codon. Here we describe the …
transfer RNA linkage in response to recognition of a stop codon. Here we describe the …
The termination of translation
S Petry, A Weixlbaumer, V Ramakrishnan - Current opinion in structural …, 2008 - Elsevier
Recent results from cryoelectron microscopy, crystallography, and biochemical experiments
have shed considerable light on the process by which protein synthesis is terminated when …
have shed considerable light on the process by which protein synthesis is terminated when …
Mechanisms that ensure speed and fidelity in eukaryotic translation termination
Translation termination, which liberates a nascent polypeptide from the ribosome specifically
at stop codons, must occur accurately and rapidly. We established single-molecule …
at stop codons, must occur accurately and rapidly. We established single-molecule …
Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is
a signature of aerobic life forms. We present a 2.2 Å resolution structure of human …
a signature of aerobic life forms. We present a 2.2 Å resolution structure of human …
Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is
a signature of aerobic life forms. We present a 2.2 Å resolution structure of human …
a signature of aerobic life forms. We present a 2.2 Å resolution structure of human …
Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release
EM Youngman, SL He, LJ Nikstad, R Green - Molecular cell, 2007 - cell.com
Peptide release on the ribosome is catalyzed in the large subunit peptidyl transferase center
by release factors on recognition of stop codons in the small subunit decoding center. Here …
by release factors on recognition of stop codons in the small subunit decoding center. Here …
O6-Methylguanosine leads to position-dependent effects on ribosome speed and fidelity
BH Hudson, HS Zaher - Rna, 2015 - rnajournal.cshlp.org
Nucleic acids are under constant assault from endogenous and environmental agents that
alter their physical and chemical properties. O 6-methylation of guanosine (m6G) is …
alter their physical and chemical properties. O 6-methylation of guanosine (m6G) is …
Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits
K Lee, R Sharma, OK Shrestha, CA Bingman… - Nature structural & …, 2016 - nature.com
Ribosome-associated J protein–Hsp70 chaperones promote nascent-polypeptide folding
and normal translational fidelity. The J protein Zuo1 is known to span the ribosomal …
and normal translational fidelity. The J protein Zuo1 is known to span the ribosomal …