Hyperthermia and protein homeostasis: Cytoprotection and cell death
Protein homeostasis or proteostasis, the correct balance between production and
degradation of proteins, is an essential pillar for proper cellular function. Among the several …
degradation of proteins, is an essential pillar for proper cellular function. Among the several …
ROSics: chemistry and proteomics of cysteine modifications in redox biology
HJ Kim, S Ha, HY Lee, KJ Lee - Mass spectrometry reviews, 2015 - Wiley Online Library
Post‐translational modifications (PTMs) occurring in proteins determine their functions and
regulations. Proteomic tools are available to identify PTMs and have proved invaluable to …
regulations. Proteomic tools are available to identify PTMs and have proved invaluable to …
[HTML][HTML] Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or
effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally …
effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally …
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia
E Khandros, CS Thom, J D'Souza… - Blood, The Journal of …, 2012 - ashpublications.org
Cells remove unstable polypeptides through protein quality-control (PQC) pathways such as
ubiquitin-mediated proteolysis and autophagy. In the present study, we investigated how …
ubiquitin-mediated proteolysis and autophagy. In the present study, we investigated how …
Targeting the heat shock response induced by modulated electro-hyperthermia (mEHT) in cancer
Abstract The Heat Shock Response (HSR) is a cellular stress reaction crucial for cell survival
against stressors, including heat, in both healthy and cancer cells. Modulated electro …
against stressors, including heat, in both healthy and cancer cells. Modulated electro …
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival
The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …
Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion
A Gonzalez-Reyes, A Menaouar, D Yip… - Molecular and cellular …, 2015 - Elsevier
Oxytocin (OT) stimulates cardioprotection. Here we investigated heart-derived H9c2 cells in
simulated ischemia–reperfusion (I–R) experiments in order to examine the mechanism of OT …
simulated ischemia–reperfusion (I–R) experiments in order to examine the mechanism of OT …
Differential gene expressions in testes of L2 strain Taiwan country chicken in response to acute heat stress
SH Wang, CY Cheng, PC Tang, CF Chen, HH Chen… - Theriogenology, 2013 - Elsevier
Acute heat stress affects genes involved in spermatogenesis in mammals. However, there is
apparently no elaborate research on the effects of acute heat stress on gene expression in …
apparently no elaborate research on the effects of acute heat stress on gene expression in …
[HTML][HTML] A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition
The naked mole-rat maintains robust proteostasis and high levels of proteasome-mediated
proteolysis for most of its exceptional (~ 31 years) life span. Here, we report that the highly …
proteolysis for most of its exceptional (~ 31 years) life span. Here, we report that the highly …
[HTML][HTML] Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13
The interaction between K48-linked ubiquitin (Ub) chain and Rpn13 is important for
proteasomal degradation of ubiquitinated substrate proteins. Only the complex structure …
proteasomal degradation of ubiquitinated substrate proteins. Only the complex structure …