Amyotrophic lateral sclerosis (ALS) is an incurable and fatal disorder characterized by the
progressive loss of motor neurons in the cerebral cortex, brain stem, and spinal cord …

Intercellular communication between neurons and their surrounding cells occurs through the
secretion of soluble molecules or release of vesicles such as exosomes into the extracellular …

Mutations in superoxide dismutase 1 (SOD1) are responsible for 20% of familial ALS. Given
the gain of toxic function in this dominantly inherited disease, lowering SOD1 mRNA and …

The noncoding genome is substantially larger than the protein-coding genome but has been
largely unexplored by genetic association studies. Here, we performed region-based rare …

While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …

MicroRNAs (miRs) are powerful regulators of CNS development and diseases. Plasma and
cerebrospinal fluid (CSF) miRs have recently been implicated as potential new sources for …

Homozygous mutation of the RNA kinase CLP1 (cleavage factor polyribonucleotide kinase
subunit 1) causes pontocerebellar hypoplasia type 10 (PCH10), a pediatric …

Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are
critically involved in neural function. Genetically manipulating astrocytes is an essential tool …

Simple Summary Amyotrophic lateral sclerosis (ALS) is a disease characterized by the
death of motor neurons that results in progressive muscle weakness and paralysis …

Amyotrophic lateral sclerosis (ALS) is a complex multi-system neurodegenerative disorder
with currently limited diagnostic and no therapeutic options. Despite the intense efforts no …