This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Resistance arteries and arterioles evolved as specialized blood vessels serving two
important functions:(a) regulating peripheral vascular resistance and blood pressure and (b) …

Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …

Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Background: Ca2+ signals in smooth muscle cells (SMCs) contribute to vascular resistance
and control blood pressure. Increased vascular resistance in hypertension has been …

ATP is well established as a transmitter and modulator in the peripheral and central nervous
system. While conventional exocytotic release of ATP at synapses occurs, this transmitter is …

Physical forces exert profound effects on cells affecting fate, function, and response to
stressors. In the case of the endothelium, the layer that resides in the inner surface of blood …

Transient receptor potential vanilloid 4 (TRPV4), a member of the TRP superfamily, is a
broadly expressed, cell surface‐localized cation channel that is activated by a variety of …

Background: Genome-wide association studies have identified hundreds of loci associated
with common vascular diseases, such as coronary artery disease, myocardial infarction, and …

A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …