Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment

J Zhu, Z Hu, Y Luo, Y Liu, W Luo, X Du, Z Luo… - Frontiers in …, 2024 - frontiersin.org
Diabetic peripheral neuropathy (DPN) refers to the development of peripheral nerve
dysfunction in patients with diabetes when other causes are excluded. Diabetic distal …

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

L Hu, W Chen, A Qian, YP Li - Bone Research, 2024 - nature.com
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N Xie, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Mind the gap: unraveling the intricate dance between Alzheimer's disease and related dementias and bone health

SJ Karnik, TJ Margetts, HS Wang, A Movila… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …

Review on the protective activity of osthole against the pathogenesis of osteoporosis

J Chen, X Liao, J Gan - Frontiers in Pharmacology, 2023 - frontiersin.org
Osteoporosis (OP), characterized by continuous bone loss and increased fracture risk, has
posed a challenge to patients and society. Long-term administration of current …

SiJunZi decoction ameliorates bone quality and redox homeostasis and regulates advanced glycation end products/receptor for advanced glycation end products and …

X Dai, Y Liu, T Liu, Y Zhang, S Wang, T Xu, J Yin… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance SiJunZi decoction (SJZD), one of the traditional Chinese
medicine formulas, has been clinically and traditionally used to improve glucose and lipid …

Common miRNAs of osteoporosis and fibromyalgia: a review

S Philippe, M Delay, N Macian, V Morel… - International Journal of …, 2023 - mdpi.com
A significant clinical association between osteoporosis (OP) and fibromyalgia (FM) has been
shown in the literature. Given the need for specific biomarkers to improve OP and FM …

Alzheimer's disease and its associated risk of bone fractures: a narrative review

BN Zhou, Q Zhang, M Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Alzheimer's disease (AD) is a neurodegenerative disorder that is the major
cause of dementia in the aged population. Recent researches indicate that patients with AD …

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Z Wu, W Li, K Jiang, Z Lin, C Qian, M Wu, Y Xia… - MedComm, 2024 - Wiley Online Library
As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation
by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction …

[HTML][HTML] The wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: An in vivo and in vitro study

Y Cai, H Sun, X Song, J Zhao, D Xu, M Liu - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Our study was performed to investigate whether the Wingless and int-1 (Wnt) signaling
pathway promotes osteogenic differentiation and inhibits apoptosis in bone marrow …