Immune cells survey and patrol throughout the body and sometimes take residence in niche
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …

Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …

CD8+ T cells are classically recognized as adaptive lymphocytes based on their ability to
recognize specific foreign antigens and mount memory responses. However, recent studies …

The success of the CD8 T cell-mediated immune response against infections and tumors
depends on the formation of a long-lived memory pool, and the protection of effector cells …

Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …

We are just beginning to understand the diversity of the peripheral T cell compartment,
which arises from the specialization of different T cell subsets and the plasticity of individual …

Historically, the immune system was believed to develop along a linear axis of maturity from
fetal life to adulthood. Now, it is clear that distinct layers of immune cells are generated from …

Memory CD8+ T cells participate in the fight against infection and tumorigenesis as well as
in autoimmune disease progression because of their efficient and rapid immune response …

Cellular metabolism of both cancer and immune cells in the acidic, hypoxic, and nutrient-
depleted tumor microenvironment (TME) has attracted increasing attention in recent years …

ABSTRACT ATP synthase inhibitory factor 1 (ATPIF1) is a mitochondrial protein with an
activity in inhibition of F1Fo-ATP synthase. ATPIF1 activity remains unknown in the control of …