Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …

Wound healing occurs as a response to disruption of the epidermis and dermis. It is an
intricate and well-orchestrated response with the goal to restore skin integrity and function …

Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic
scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major …

Fibrocytes are circulating, hematopoietic cells that express CD45 and Col1a1. They
contribute to wound healing and several fibrosing disorders by mechanisms that are poorly …

The pathogenesis of keloids has not been elucidated, and the disease is thought to be
caused by abnormal secretion of proinflammatory mediators and irregular responses to …

Rationale: Hypersensitivity pneumonitis (HP) represents a lung inflammation provoked by
exposure to a variety of antigens. Chronic HP may evolve to lung fibrosis. Bone marrow …

Significance: Both chronic wounds and excessive scar formation after cutaneous injury
create a formidable clinical problem resulting in considerable morbidity and healthcare …