The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

The nucleic acid therapeutics field has made tremendous progress in the past decades.
Continuous advances in chemistry and design have led to many successful clinical …

Seeds are a vital source of calories for humans and a unique stage in the life cycle of
flowering plants. During seed germination, the embryo undergoes major developmental …

Oligonucleotide gene therapy (OGT) agents (eg antisense, deoxyribozymes, siRNA and
CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs …

Since the start of the coronavirus disease 2019 (COVID‐19) pandemic, new variants of
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have emerged …

Glutamine metabolism is critical both for the proliferation of cancer cells and the activation of
CD8T cells to kill cancer cells. We aim to explore the relationship between the glutamine …

Background Lactate is an important metabolite derived from glycolysis under physiological
and pathological conditions. The Warburg effect reveals the vital role of lactate in cancer …

COVID-19 has had an impact on human quality of life and economics. Scientists have been
identifying remedies for its prevention and treatment from all possible sources, including …