The next-generation sequencing technologies are being rapidly applied in biological
research. Tens of millions of short sequences generated in a single experiment provide us …

Experimental design has a long tradition in statistics, engineering and life sciences, dating
back to the beginning of the last century when optimal designs for industrial and agricultural …

A comprehensive approach to sample size determination and power with applications for a
variety of fields Sample Size Determination and Power features a modern introduction to the …

Praise for the Second Edition:"… this is a useful, comprehensive compendium of almost
every possible sample size formula. The strong organization and carefully defined formulae …

Motivation: In microarray data studies most researchers are keenly aware of the potentially
high rate of false positives and the need to control it. One key statistical shift is the move …

DNA microarrays are an important technology for studying gene expression. With a single
hybridization, the level of expression of thousands of genes, or even an entire genome, can …

Data snooping is a major concern in empirical asset pricing. We develop a new framework
to rigorously perform multiple hypothesis testing in linear asset pricing models, while limiting …

We consider the choice of an optimal sample size for multiple-comparison problems. The
motivating application is the choice of the number of microarray experiments to be carried …

We are coming to appreciate that at fertilization human spermatozoa deliver the paternal
genome alongside a suite of structures, proteins and RNAs. Although the role of some of the …

Background The analysis of large-scale gene expression data is a fundamental approach to
functional genomics and the identification of potential drug targets. Results derived from …