Once and only once: mechanisms of centriole duplication and their deregulation in disease
EA Nigg, AJ Holland - Nature reviews Molecular cell biology, 2018 - nature.com
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
Determinants and clinical implications of chromosomal instability in cancer
L Sansregret, B Vanhaesebroeck… - Nature reviews Clinical …, 2018 - nature.com
Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …
chromosomal alterations, is one of the most common characteristics of cancer genomes …
Mechanisms generating cancer genome complexity from a single cell division error
INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …
mutational process, common during tumorigenesis, that results in gene amplification and …
Mechanism of spindle pole organization and instability in human oocytes
C So, K Menelaou, J Uraji, K Harasimov, AM Steyer… - Science, 2022 - science.org
Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer
R Gao, A Davis, TO McDonald, E Sei, X Shi, Y Wang… - Nature …, 2016 - nature.com
Aneuploidy is a hallmark of breast cancer; however, knowledge of how these complex
genomic rearrangements evolve during tumorigenesis is limited. In this study, we developed …
genomic rearrangements evolve during tumorigenesis is limited. In this study, we developed …
Mitotic spindle assembly in animal cells: a fine balancing act
SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …
into the two daughter cells during cell division, which is paramount for maintaining genome …
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Dystrophin is expressed in differentiated myofibers, in which it is required for sarcolemmal
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …
Centrosome function and assembly in animal cells
PT Conduit, A Wainman, JW Raff - Nature reviews Molecular cell …, 2015 - nature.com
It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …
microtubule organizers. There is increasing evidence that they also function as coordination …
Cytokinesis defects and cancer
SMA Lens, RH Medema - Nature Reviews Cancer, 2019 - nature.com
Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …
Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel
CM Scribano, J Wan, K Esbona, JB Tucker… - Science translational …, 2021 - science.org
Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of
cytotoxicity is incompletely understood and not all patients benefit from treatment. We show …
cytotoxicity is incompletely understood and not all patients benefit from treatment. We show …