Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Aneuploidy is a hallmark of breast cancer; however, knowledge of how these complex
genomic rearrangements evolve during tumorigenesis is limited. In this study, we developed …

The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Dystrophin is expressed in differentiated myofibers, in which it is required for sarcolemmal
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of
cytotoxicity is incompletely understood and not all patients benefit from treatment. We show …