Regulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for
telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

An important advance in cancer therapy has been the development of poly (ADP-ribose)
polymerase (PARP) inhibitors for the treatment of homologous recombination (HR)-deficient …

Transcription-replication conflict is a major cause of replication stress that arises when
replication forks collide with the transcription machinery. Replication fork stalling at sites of …

Understanding how chromatin organisation is duplicated on the two daughter strands is a
central question in epigenetics. In mammals, following the passage of the replisome …

RNA: DNA hybrids compromise replication fork progression and genome integrity in all cells.
The overall impacts of naturally occurring RNA: DNA hybrids on genome integrity, and the …

R-loops are three-stranded nucleic acid structures that can cause replication stress by
blocking replication fork progression. However, the detailed mechanism underlying the …

Unscheduled R-loops are a major source of replication stress and DNA damage. R-loop-
induced replication defects are sensed and suppressed by ATR kinase, whereas it is not …

DNA replication and transcription occur in all living cells across all domains of life. Both
essential processes occur simultaneously on the same template, leading to conflicts …

Simple Summary R-loops are three-stranded structures consisting of an RNA–DNA hybrid
and an unpaired single-stranded DNA (ssDNA), with biological implications in cellular …