The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?
The intervertebral disc (IVD) is a complex tissue, and its degeneration remains a problem for
patients, without significant improvement in treatment strategies. This mostly age-related …
patients, without significant improvement in treatment strategies. This mostly age-related …
The role of tendon derived stem/progenitor cells and extracellular matrix components in the bone tendon junction repair
Q Shengnan, S Bennett, W Wen, L Aiguo, X Jiake - Bone, 2021 - Elsevier
Fibrocartilage enthesis is the junction between bone and tendon with a typical
characteristics of fibrocartilage transition zones. The regeneration of this transition zone is …
characteristics of fibrocartilage transition zones. The regeneration of this transition zone is …
Modic changes are associated with activation of intense inflammatory and host defense response pathways–molecular insights from proteomic analysis of human …
S Rajasekaran, DCR Soundararajan, SM Nayagam… - The Spine Journal, 2022 - Elsevier
ABSTRACT BACKGROUND CONTEXT Patients with modic changes (MC) form a distinct
clinical subset with reports of higher intensity of pain, poor clinical and surgical outcomes …
clinical subset with reports of higher intensity of pain, poor clinical and surgical outcomes …
Identification of a potential novel biomarker in intervertebral disk degeneration by bioinformatics analysis and experimental validation
Z Yang, ZZ Yuan, XL Ma - Frontiers in Immunology, 2023 - frontiersin.org
Background Intervertebral disk degeneration (IVDD) is a major cause of low back pain and
one of the most common health problems all over the world. However, the early diagnosis of …
one of the most common health problems all over the world. However, the early diagnosis of …
Regenerative capability of human nucleus pulposus cells in degenerated disc under hydrostatic pressure mimicking physiologically relevant intradiscal pressure in …
Y Takeoka, Y Kanda, JD Kang, S Mizuno - Spine, 2023 - journals.lww.com
Study Design. Isolated human nucleus pulposus (hNP) cells from the degenerated
intervertebral disc (IVD) were incubated under hydrostatic pressure (HP) and evaluated for …
intervertebral disc (IVD) were incubated under hydrostatic pressure (HP) and evaluated for …
[HTML][HTML] Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice
Embryonic muscle forces are necessary for normal vertebral development and spinal
curvature, but their involvement in intervertebral disc (IVD) development remains unclear …
curvature, but their involvement in intervertebral disc (IVD) development remains unclear …
椎间盘退变中胶原蛋白的代谢失衡
董亦直， 宋鑫越， 姚鸣宇， 朱赫， 吴瑞霞， 都亚新， 祝勇 - 中国组织工程研究, 2025 - cjter.com
椎间盘退变中胶原蛋白的代谢失衡 Page 1 Chinese Journal of Tissue Engineering Research|Vol
29|No.14|May 2025|3011 中国组织工程研究 Chinese Journal of Tissue Engineering Research …
29|No.14|May 2025|3011 中国组织工程研究 Chinese Journal of Tissue Engineering Research …
Current status of the instructional cues provided by notochordal cells in novel disc repair strategies
Numerous publications over the past 22 years, beginning with a seminal paper by Aguiar et
al., have demonstrated the ability of notochordal cell-secreted factors to confer anabolic …
al., have demonstrated the ability of notochordal cell-secreted factors to confer anabolic …
Collagen metabolism imbalance in intervertebral disc degeneration
Y Dong, X Song, M Yao, H Zhu, R Wu… - Chinese Journal of …, 2025 - cjter.com
BACKGROUND: Lumbar disc degeneration is a common disease that causes lower back
pain and lower limb neurological symptoms. The balance of collagen metabolism plays an …
pain and lower limb neurological symptoms. The balance of collagen metabolism plays an …
Перспективы таргетной терапии неспецифической боли в спине: обзор последних публикаций
ТМ Маневич, ЭА Мхитарян… - Российский журнал …, 2021 - geriatr-news.com
Аннотация Высокая частота встречаемости боли в спине у лиц пожилого возраста, ее
влияние на качество и продолжительность жизни, недостаточная эффективность …
влияние на качество и продолжительность жизни, недостаточная эффективность …